Jian W G, Darnton S J, Jenner K, Billingham L J, Matthews H R
Department of Thoracic Surgery, Birmingham Heartlands Hospital, UK.
J Clin Pathol. 1997 Aug;50(8):640-4. doi: 10.1136/jcp.50.8.640.
To study the expression and prognostic significance of the cell adhesion molecule E-cadherin in oesophageal tumours from the UK (low risk area) and China (high risk area).
E-cadherin expression was measured immunohistochemically in resected tumours from 17 patients in the UK with adenocarcinoma, 23 patients from the UK with squamous carcinoma, and 30 patients from China with squamous carcinomas who survived for five years postoperatively and compared with similar tumours from patients in the same regions who did not survive (140 tumours in all).
Normal squamous epithelial cells and well differentiated areas of tumours showed membranous staining for E-cadherin expression. Cytoplasmic staining, heterogeneous staining, or an absence of staining was seen in dysplastic epithelium and in less well differentiated areas of tumours. Only one of 140 primary tumours had homogeneous membranous expression. In tumours from UK patients with adenocarcinoma (p = 1.00) and from Chinese patients with squamous carcinomas (p = 0.06) there was no correlation between E-cadherin absence and non-survival. In tumours from UK patients with squamous carcinomas there was a significant correlation between absence of E-cadherin and non-survival (p = 0.009). Tumours from UK patients with squamous carcinoma who survived were significantly less likely to be E-cadherin absent than those from Chinese patients with squamous carcinomas who survived (p = 0.007). Multivariate analysis (n = 37 UK, paired data) showed that absence of E-cadherin in the primary tumour was a weak independent prognostic factor for non-survival (30% significance level; p = 0.26; odds ratio = 3.56). In UK nodal metastases there was no correlation between E-cadherin expression and survival.
Squamous carcinomas from UK patients differed from both adenocarcinomas from UK patients and carcinomas from Chinese patients with respect to E-cadherin expression and prognostic significance. In tumours from UK patients, E-cadherin absence in the primary carcinoma (a weak independent prognostic factor) but not metastases correlated with non-survival.
研究细胞黏附分子E-钙黏蛋白在英国（低风险地区）和中国（高风险地区）食管肿瘤中的表达及预后意义。
采用免疫组织化学方法检测17例英国腺癌患者、23例英国鳞癌患者以及30例术后存活5年的中国鳞癌患者手术切除肿瘤中E-钙黏蛋白的表达，并与来自同一地区未存活患者的相似肿瘤（共140个肿瘤）进行比较。
正常鳞状上皮细胞和肿瘤的高分化区域显示E-钙黏蛋白表达呈膜性染色。发育异常的上皮以及肿瘤的低分化区域可见细胞质染色、异质性染色或无染色。140个原发性肿瘤中只有1个具有均匀的膜性表达。在英国腺癌患者的肿瘤（p = 1.00）和中国鳞癌患者的肿瘤（p = 0.06）中，E-钙黏蛋白缺失与未存活之间无相关性。在英国鳞癌患者的肿瘤中，E-钙黏蛋白缺失与未存活之间存在显著相关性（p = 0.009）。存活的英国鳞癌患者的肿瘤E-钙黏蛋白缺失的可能性明显低于存活的中国鳞癌患者的肿瘤（p = 0.007）。多因素分析（n = 37例英国患者，配对数据）显示，原发性肿瘤中E-钙黏蛋白缺失是未存活的一个弱独立预后因素（显著性水平为30%；p = 0.26；比值比 = 3.56）。在英国的区域淋巴结转移中，E-钙黏蛋白表达与存活无相关性。
英国患者的鳞癌在E-钙黏蛋白表达及预后意义方面与英国腺癌患者的肿瘤以及中国患者的肿瘤均不同。在英国患者的肿瘤中，原发性癌中E-钙黏蛋白缺失（一个弱独立预后因素）而非转移与未存活相关。
