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[风险因素高脂蛋白血症的临床意义。对2700例患者的研究]

[The clinical significance of the risk factor hyperlipoproteinemia. Study on 2700 patients].

作者信息

Dabels J, Rinke E

出版信息

Z Gesamte Inn Med. 1977 Jul 1;32(13):194-6.

PMID:930179
Abstract

In a clinical study on 2,700 inpatients of the medical clinic of Rostock University systematic examinations of the lipids and lipoproteins were carried out. 2.5% of the examined patients showed a primary hyperlipoproteinemia, 14,8% disturbances of the lipid metabolism of different degree of severity, taking into consideration borderline regions of 300 mg/100 ml for cholesterol and of 250 mg/100 ml for triglycerides. In coronary sclerosis and myocardial infarction the frequency of hyperlipoproteinemia was, as we expected, very high, it was about 63 and 77%, respectively. In part groups in primary hyperlipoproteinemia as additional examinations the triglyceride content in the material of liver punction, various coagulation parameters, such as function and kinetics of the platelets were determined and examinations of the secretion of the exocrine pancreas were carried out. In patients of the programme of chronic dialysis, apart from this in temporary dependence on the treatment determinations of the heparin-induced lipoprotein lipase were performed. The consequences resulting from the mutual relations of the factor of risk hyperlipoproteinemia to the diseases of various organic systems are shown.

摘要

在罗斯托克大学医学诊所对2700名住院患者进行的一项临床研究中,对脂质和脂蛋白进行了系统检查。考虑到胆固醇300mg/100ml和甘油三酯250mg/100ml的临界范围,2.5%的受检患者表现为原发性高脂蛋白血症,14.8%的患者存在不同严重程度的脂质代谢紊乱。正如我们所预期的,在冠状动脉硬化和心肌梗死患者中,高脂蛋白血症的发生率非常高,分别约为63%和77%。在原发性高脂蛋白血症的部分亚组中,作为附加检查,测定了肝穿刺材料中的甘油三酯含量、各种凝血参数,如血小板功能和动力学,并对外分泌胰腺的分泌进行了检查。在慢性透析项目的患者中,除了临时依赖治疗外,还进行了肝素诱导的脂蛋白脂肪酶的测定。展示了高脂蛋白血症风险因素与各种有机系统疾病之间相互关系所产生的后果。

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