Cohen M A, Huband M D, Gage J W, Yoder S L, Roland G E, Gracheck S J
Therapeutics Department, Parke-Davis Pharmaceutical Research, Division of Warner Lambert Company, Ann Arbor, MI 48105-2495, USA.
J Antimicrob Chemother. 1997 Aug;40(2):205-11. doi: 10.1093/jac/40.2.205.
Clinafloxacin and trovafloxacin are two new fluoroquinolones for which few comparative data are available. When MICs of ciprofloxacin against Gram-positive and Gram-negative nosocomial species were compared, clinafloxacin was the most potent although trovafloxacin was also more active than ciprofloxacin against Staphylococcus aureus and enterococci. All three drugs were bactericidal. Clinafloxacin displayed the lowest frequency of resistance, approximating 10(-11). Development of resistance studies over 13-14 passages in the presence of drug revealed a 32-fold increase in MIC of clinafloxacin against S. aureus compared with 512- and 1024-fold for trovafloxacin and ciprofloxacin respectively, although the three drugs were comparable against Enterococcus faecalis and the Gram-negative bacilli.
克林沙星和曲伐沙星是两种新型氟喹诺酮类药物，目前关于它们的比较数据很少。当比较环丙沙星对革兰氏阳性和革兰氏阴性医院感染菌的最低抑菌浓度（MIC）时，克林沙星的活性最强，尽管曲伐沙星对金黄色葡萄球菌和肠球菌的活性也比环丙沙星高。这三种药物均具有杀菌作用。克林沙星的耐药频率最低，约为10^(-11)。在有药物存在的情况下进行13 - 14代的耐药性研究发现，克林沙星对金黄色葡萄球菌的MIC增加了32倍，而曲伐沙星和环丙沙星分别增加了512倍和1024倍，不过这三种药物对粪肠球菌和革兰氏阴性杆菌的作用相当。
