通过特异性辅助性T细胞2克隆的过继转移，可在乙型肝炎e抗原（HBeAg）转基因小鼠中诱导产生抗HBeAg抗体。
Antibodies to the hepatitis B e antigen (HBeAg) can be induced in HBeAg-transgenic mice by adoptive transfer of a specific T-helper 2 cell clone.
作者信息
Hultgren C, Milich D R, Sällberg M
机构信息
Division of Clinical Virology, Huddinge University Hospital, Sweden.
出版信息
Clin Diagn Lab Immunol. 1997 Sep;4(5):630-2. doi: 10.1128/cdli.4.5.630-632.1997.
Abstract
Production of antibody to hepatitis B e antigen (HBeAg); i.e., anti-HBe antibody,) in HBeAg-transgenic mice is believed to be mediated by T-helper 2 (Th2) cells. Injection of an HBeAg-specific Th2 clone into HBeAg-transgenic H-2k mice induced anti-HBe antibody production, confirming the function of Th2 cells in this model system.
摘要
在乙肝e抗原（HBeAg）转基因小鼠中，抗乙肝e抗原抗体（即抗-HBe抗体）的产生被认为是由辅助性T细胞2（Th2）介导的。将HBeAg特异性Th2克隆注射到HBeAg转基因H-2k小鼠中可诱导抗-HBe抗体产生，这证实了Th2细胞在该模型系统中的作用。
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