Pizarro-Cerdá J, Moreno E, Desjardins M, Gorvel J P
Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Histol Histopathol. 1997 Oct;12(4):1027-38.
Cellular microbiology has recently been described as a new discipline emerging at the interface between cell biology and microbiology (Cossart et al., 1996). Many microbial pathogens can enter eukaryotic cells and live intracellularly either inside vacuoles or in the cytoplasm. The different steps during the invasion process are on the way of being dissected at the molecular level revealing new insights in basic cellular functions. Indeed, bacterial pathogenesis can help us to better understand the dynamics of cell cytoskeleton, intracellular membrane traffic and signal transduction events. The recent advancements in the field of microbial pathogenesis are creating a new cross-talk between cell biologists, microbiologists and immunologists. In this review, the different strategies used by several pathogens are presented and the mechanisms elaborated by host cells from the immune system to eliminate the parasites discussed.
细胞微生物学最近被描述为一门在细胞生物学和微生物学交叉领域中新兴的学科（科萨尔等人，1996年）。许多微生物病原体能够进入真核细胞，并在细胞内的液泡或细胞质中生存。入侵过程中的不同步骤正在分子水平上被剖析，从而揭示了基本细胞功能的新见解。事实上，细菌致病机制有助于我们更好地理解细胞细胞骨架、细胞内膜运输和信号转导事件的动态过程所涉及的机制。微生物致病领域的最新进展正在细胞生物学家、微生物学家和免疫学家之间建立新的交流。在这篇综述中，我们介绍了几种病原体所采用的不同策略，并讨论了宿主免疫系统细胞为消除这些寄生虫所阐述的机制。
