Pennati G, Bellotti M, Fumero R
Department of Bioengineering, Politecnico di Milano, Italy.
Med Eng Phys. 1997 Jun;19(4):327-35. doi: 10.1016/s1350-4533(97)84634-6.
A lumped parameter model of the human foetal circulation primarily based on blood velocity data derived from the Doppler analysis was developed in this study. It consists of two major parts, the heart and the foetal vascular circulation. The heart model accounts for both ventricular and atrial contractility. The circulation was divided into 19 compliant vascular compartments in order to describe all of the clinically monitored sites. The model parameters refer to the final gestation period and were derived either from literature on foetal sheep circulation or from anatomical dimension monitoring of the human foetus. No control mechanism is incorporated into the model. The model was validated by comparing several index values of simulated velocity curves to those of the experimental Doppler waveforms. The mean and maximum percentual errors in the estimation of the experimental results by the model are 7.7% and 20.1%, respectively. Velocity and pressure tracings of the foetal circulation were investigated, as well as regional blood flow rate distribution.
本研究建立了一个主要基于多普勒分析得出的血流速度数据的人体胎儿循环集总参数模型。它由两个主要部分组成，即心脏和胎儿血管循环。心脏模型考虑了心室和心房的收缩性。为了描述所有临床监测部位，循环被划分为19个顺应性血管腔室。模型参数参考了妊娠末期，其来源要么是关于胎儿绵羊循环的文献，要么是对人类胎儿的解剖尺寸监测。该模型未纳入控制机制。通过将模拟速度曲线的几个指标值与实验多普勒波形的指标值进行比较，对模型进行了验证。模型估计实验结果的平均百分比误差和最大百分比误差分别为7.7%和20.1%。研究了胎儿循环的速度和压力描记，以及局部血流速率分布。
