Lachmann R H, Efstathiou S
Dept. of Pathology, University of Cambridge, UK.
Mol Med Today. 1997 Sep;3(9):404-11. doi: 10.1016/S1357-4310(97)01106-4.
The ability of herpes simplex virus (HSV) to establish a lifelong, latent infection within neurons has led to much interest in the development of HSV-based vectors for neuronal gene delivery. This review discusses the progress made towards the construction of safe, replication-disabled HSV vectors that are capable of directing long-term transgene expression in latently infected neurons. Such vectors are now being investigated in a variety of animal model systems, with a view to developing gene therapy approaches to a number of metabolic and degenerative neurological diseases.
单纯疱疹病毒（HSV）在神经元内建立终身潜伏感染的能力，引发了人们对开发基于HSV的神经元基因递送载体的浓厚兴趣。本综述讨论了在构建安全的、复制缺陷型HSV载体方面所取得的进展，这些载体能够在潜伏感染的神经元中指导长期转基因表达。目前正在多种动物模型系统中研究此类载体，以期开发针对多种代谢性和退行性神经疾病的基因治疗方法。
