Szydlowska T
Zentralbl Bakteriol Orig A. 1977 Oct;239(2):270-4.
Resensibilization in vitro to seven antibiotics under the influence of DMSO was studied in 624 resistant strains of five species of bacteria (E. coli, S. typhi, S. pyogenes, S. viridans, S. aureus), 61 strains of tubercle bacilli resistant to isonicotinic acid hydrazide (INH) and 19 strains of tubercle bacilli resistant to rifampicin (RMP). DMSO in concentrations of 0.1-10.0% caused reversion of sensitivity in strains of E. coli, S. pyogenes and S. viridans. Reversion in vivo of sensitivity to INH of tubercle bacilli was studied in experimental tuberculosis of guinea pigs. Tubercle bacilli previously resistant to INH recovered complete sensitivity to the drug, enabling animals infected with the INH-resistant strain of bacilli to be treated with INH.
在624株5种细菌(大肠杆菌、伤寒沙门氏菌、化脓性链球菌、草绿色链球菌、金黄色葡萄球菌)的耐药菌株、61株对异烟肼(INH)耐药的结核杆菌菌株以及19株对利福平(RMP)耐药的结核杆菌菌株中,研究了在二甲基亚砜(DMSO)影响下对7种抗生素的体外再致敏情况。浓度为0.1 - 10.0%的DMSO可使大肠杆菌、化脓性链球菌和草绿色链球菌菌株的敏感性发生逆转。在豚鼠实验性结核病中研究了结核杆菌对INH敏感性的体内逆转情况。先前对INH耐药的结核杆菌恢复了对该药物的完全敏感性,使得感染INH耐药菌株的动物能够用INH进行治疗。