Li J, Chen G, Webster J M
Department of Biological Sciences, Simon Fraser University, Vancouver, B.C., Canada.
Can J Microbiol. 1997 Aug;43(8):770-3. doi: 10.1139/m97-110.
A new antibiotic, nematophin, was isolated from strain BC1 of Xenorhabdus nematophilus and detected in all strains of X. nematophilus studied. Its structure is fully established as 3-indoleethyl (3'-methyl-2'-oxo)pentanamide by extensive spectroscopic study. The production of nematophin is affected by the strain type and culture conditions. The compound shows strong in vitro bioactivity against a series of fungal and bacterial species.
一种新的抗生素——线虫菌素，是从嗜线虫致病杆菌BC1菌株中分离出来的，在所研究的所有嗜线虫致病杆菌菌株中均能检测到。通过广泛的光谱研究，其结构已完全确定为3-吲哚乙基（3'-甲基-2'-氧代）戊酰胺。线虫菌素的产生受菌株类型和培养条件的影响。该化合物对一系列真菌和细菌物种具有很强的体外生物活性。
