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表皮生长因子刺激产生甲胎蛋白的大鼠肝癌细胞的增殖。

Epidermal growth factor stimulates proliferation of rat hepatoma cells producing alpha-fetoprotein.

作者信息

Kaneko Y, Imai Y, Matsuzaki F, Endo Y, Oda T

出版信息

Experientia. 1979 Dec 15;35(12):1060-1. doi: 10.1007/BF01953254.

DOI:10.1007/BF01953254
PMID:93054
Abstract

Epidermal growth factor stimulated both [3H]thymidine uptake and proliferation of rat AH66 hepatoma cells. However, the increase in cell number was not accompanied by a proportional increase in the levels of alpha-fetoprotein of the culture media. The effects of EGF on the cell proliferation were antagonized by N6,O2'-dibutyryl cAMP.

摘要

表皮生长因子刺激了大鼠AH66肝癌细胞的[3H]胸腺嘧啶核苷摄取和增殖。然而，细胞数量的增加并未伴随着培养基中甲胎蛋白水平的相应增加。N6,O2'-二丁酰环磷腺苷对抗了表皮生长因子对细胞增殖的影响。

相似文献

1
Epidermal growth factor stimulates proliferation of rat hepatoma cells producing alpha-fetoprotein.表皮生长因子刺激产生甲胎蛋白的大鼠肝癌细胞的增殖。
Experientia. 1979 Dec 15;35(12):1060-1. doi: 10.1007/BF01953254.
2
Effect of phorbol esters and hormones on rat hepatoma cells producing alpha-fetoprotein.佛波酯和激素对产生甲胎蛋白的大鼠肝癌细胞的影响。
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Transforming growth factor-beta 1 stimulates proliferation of Morris hepatoma cells in serum-free soft agar culture system supplemented with EGF and insulin.转化生长因子-β1在补充了表皮生长因子（EGF）和胰岛素的无血清软琼脂培养系统中刺激莫里斯肝癌细胞的增殖。
Cancer Lett. 1990 Oct 8;54(1-2):51-6. doi: 10.1016/0304-3835(90)90090-k.
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Differential regulation of albumin gene expression by heparin-binding epidermal growth factor-like growth factor in alpha-fetoprotein-producing and -nonproducing human hepatoma cells.肝素结合表皮生长因子样生长因子对产甲胎蛋白和不产甲胎蛋白的人肝癌细胞中白蛋白基因表达的差异调节
Tumour Biol. 1999 May-Jun;20(3):130-8. doi: 10.1159/000030055.
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Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-beta on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation.表皮生长因子、生长调节素-C/胰岛素样生长因子I以及转化生长因子-β对猪颗粒细胞脱氧核糖核酸合成及细胞增殖的不同作用
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Epidermal growth factor induction of cellular proliferation and protooncogene expression in growth-arrested rat H4IIE hepatoma cells: role of cyclic adenosine monophosphate.表皮生长因子对生长停滞的大鼠H4IIE肝癌细胞增殖及原癌基因表达的诱导作用：环磷酸腺苷的作用
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Effects of hexamethylene bisacetamide on alpha-fetoprotein, albumin, and transferrin production by two rat hepatoma cell lines.六亚甲基双乙酰胺对两种大鼠肝癌细胞系甲胎蛋白、白蛋白和转铁蛋白生成的影响
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Production of alpha-fetoprotein by cultured rat ascites hepatoma cells determined in vivo as alpha-fetoprotein-negative.通过体内测定为甲胎蛋白阴性的培养大鼠腹水肝癌细胞产生甲胎蛋白。
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Inhibition of hepatoma cell growth by analogs of adenosine and cyclic AMP and the influence of enzymes in mammalian sera.腺苷和环磷酸腺苷类似物对肝癌细胞生长的抑制作用以及哺乳动物血清中酶的影响。
J Cell Physiol. 1982 Jun;111(3):232-8. doi: 10.1002/jcp.1041110303.
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Regulation of alpha-fetoprotein and transferrin synthesis and secretion in mouse hepatoma cells.小鼠肝癌细胞中甲胎蛋白和转铁蛋白合成与分泌的调控
Arch Biochem Biophys. 1982 Oct 15;218(2):592-602. doi: 10.1016/0003-9861(82)90384-8.

引用本文的文献

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本文引用的文献

1
Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization.表皮生长因子及一种新衍生物。快速分离方法以及生物学和化学特性
J Biol Chem. 1972 Dec 10;247(23):7609-11.
2
Epidermal growth factor: receptors in human fibroblasts and modulation of action by cholera toxin.表皮生长因子：人成纤维细胞中的受体以及霍乱毒素对其作用的调节
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2964-8. doi: 10.1073/pnas.70.10.2964.
3
The isolation of the urogastrones - inhibitors of gastric acid secretion - from human urine.
从人尿中分离出尿抑胃素——胃酸分泌抑制剂。
Hoppe Seylers Z Physiol Chem. 1975 Nov;356(11):1765-74. doi: 10.1515/bchm2.1975.356.2.1765.
4
Hormonal stimulation of DNA synthesis in primary cultures of adult rat hepatocytes.成年大鼠肝细胞原代培养中DNA合成的激素刺激作用。
Proc Natl Acad Sci U S A. 1976 Oct;73(10):3589-93. doi: 10.1073/pnas.73.10.3589.
5
125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.125I标记的人表皮生长因子。在人成纤维细胞中的结合、内化和降解
J Cell Biol. 1976 Oct;71(1):159-71. doi: 10.1083/jcb.71.1.159.
6
Human epidermal growth factor and the proliferation of human fibroblasts.人表皮生长因子与人成纤维细胞的增殖
J Cell Physiol. 1976 Jun;88(2):227-37. doi: 10.1002/jcp.1040880212.
7
Epidermal growth factor stimulates secretion of human chorionic gonadotropin by cultured human choriocarcinoma cells.表皮生长因子刺激培养的人绒毛膜癌细胞分泌人绒毛膜促性腺激素。
J Clin Endocrinol Metab. 1978 Jan;46(1):169-72. doi: 10.1210/jcem-46-1-169.
8
Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes.表皮生长因子与培养的人表皮角质形成细胞的增殖
Nature. 1977 Feb 3;265(5593):421-4. doi: 10.1038/265421a0.
9
Insulin and epidermal growth factor. Human fibroblast receptors related to deoxyribonucleic acid synthesis and amino acid uptake.胰岛素与表皮生长因子。与脱氧核糖核酸合成及氨基酸摄取相关的人成纤维细胞受体。
J Biol Chem. 1975 May 25;250(10):3845-53.
10
Protein synthesis by rat transplantable yolk sac tumor and its relation to the cytosol levels of translatable messenger RNA's.大鼠可移植性卵黄囊瘤的蛋白质合成及其与可翻译信使核糖核酸胞质溶胶水平的关系。
Cancer Res. 1978 Dec;38(12):4728-33.