[氯苯氧异丁酸镁与肌醇六烟酸酯组合的药代动力学]
[Pharmacokinetics of a combination of magnesium-chlorophenoxy-isobutyrate and meso-inositol hexanicotinate].
作者信息
Paltauf F, Pristautz H, el Eisch I A
出版信息
Acta Med Austriaca. 1977;4(3):120-4.
The absorption, blood level and renal excretion of chlorphenoxyisobutyric acid (clofibric acid) were examined following oral dosage of the magnesium salt (magnesium clofibrate) in a combination preparation containing meso-inositol hexanicotinate. Absorption of clofibric acid was found to be identical with that obtained with ethyl-alpha-p-chlorphenoxyisobutyrate (Clofibrate) reaching almost 100%. After dosage with the combination preparation, the maximum blood level of clofibric acid was achieved after 2 hours, in contrast to 4 hours for Clofibrate. No accumulation of clofibric acid in the blood was found after 60 days treatment with combination preparation at a daily dosage of 3 tablets. Urinary excretion of clofibric acid for both the combination drug and Clofibrate was 90% in 48 hours.
在含有肌醇六烟酸酯的复方制剂中口服镁盐（氯贝酸镁）后，对氯苯氧异丁酸（氯贝酸）的吸收、血药浓度及肾排泄进行了研究。发现氯贝酸的吸收与用α-对氯苯氧异丁酸乙酯（氯贝特）时相同，吸收率几乎达到100%。服用该复方制剂后，氯贝酸在2小时后达到最高血药浓度，而氯贝特则为4小时。每日服用3片复方制剂治疗60天后，未发现氯贝酸在血液中蓄积。复方制剂和氯贝特的氯贝酸在48小时内的尿排泄率均为90%。
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