Neugut A I, Ahsan H, Antman K H
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA.
Cancer. 1997 Sep 1;80(5):948-50. doi: 10.1002/(sici)1097-0142(19970901)80:5<948::aid-cncr17>3.0.co;2-w.
Although usually associated with asbestos exposure, a number of case reports have noted the occurrence of malignant pleural mesothelioma in patients who received radiotherapy (RT) to the thorax.
The authors performed a retrospective cohort study utilizing 251,750 women registered with breast carcinoma in the Surveillance, Epidemiology, and End Results Program of the U.S. National Cancer Institute from 1973-1993, 24.8% of whom received RT as part of their initial management, and 13,743 people with Hodgkin's disease, 50.6% of whom received RT as part of their initial management.
Six cases of malignant pleural mesothelioma were found: two in breast carcinoma patients treated with RT and four found in women not treated with RT. No cases occurred in the patients with Hodgkin's disease. The overall estimated relative risk for malignant pleural mesothelioma after RT was 1.56 (95% confidence interval, 0.18-5.63).
To the authors' knowledge, this is the first controlled study to investigate thoracic radiation exposure and malignant pleural mesothelioma, and no association was found.
虽然恶性胸膜间皮瘤通常与接触石棉有关，但一些病例报告指出，接受胸部放疗（RT）的患者也会发生该疾病。
作者进行了一项回顾性队列研究，利用了1973年至1993年在美国国家癌症研究所监测、流行病学和最终结果计划中登记的251,750名乳腺癌女性患者，其中24.8%的患者在初始治疗中接受了放疗；以及13,743名霍奇金病患者，其中50.6%的患者在初始治疗中接受了放疗。
发现6例恶性胸膜间皮瘤：2例在接受放疗的乳腺癌患者中，4例在未接受放疗的女性中。霍奇金病患者中未出现病例。放疗后恶性胸膜间皮瘤的总体估计相对风险为1.56（95%置信区间，0.18 - 5.63）。
据作者所知，这是第一项研究胸部辐射暴露与恶性胸膜间皮瘤关系的对照研究，未发现两者之间存在关联。
