Suzuki M, Nomura C, Odaka H, Ikeda H
Pharmaceutical Research Division, Takeda Chemical Industries Ltd., Osaka, Japan.
Jpn J Pharmacol. 1997 Aug;74(4):297-302. doi: 10.1254/jjp.74.297.
To determine whether insulin resistance is responsible for the development of hypertension, we examined whether blood pressure changes in an insulin-resistant animal that was given a fructose solution as their drinking water. Wistar Kyoto rats that drank a 10% fructose solution for 10 weeks showed significant increases not only in plasma triglyceride and insulin levels but also in systolic blood pressure. The decrease in blood glucose in response to the intraperitoneal injection of insulin (0.2-1.0 U/kg) was slight in these fructose-drinking rats. To confirm whether insulin resistance contributes to the observed hypertension, we examined the effect of pioglitazone, an insulin sensitizer, on blood pressure in rats given a 10% fructose solution. When pioglitazone was administered to the rats at a dose of 10 mg/kg/day for 4 weeks from 12 weeks of age, plasma triglyceride and insulin levels and systolic blood pressure decreased, and blood glucose reduction in response to insulin was normalized. These results suggest that insulin resistance is responsible for the development of hypertension in fructose-drinking rats.
为了确定胰岛素抵抗是否是高血压发展的原因，我们研究了给予果糖溶液作为饮用水的胰岛素抵抗动物的血压变化情况。饮用10%果糖溶液10周的Wistar Kyoto大鼠不仅血浆甘油三酯和胰岛素水平显著升高，收缩压也显著升高。在这些饮用果糖的大鼠中，腹腔注射胰岛素（0.2 - 1.0 U/kg）后血糖的降低幅度很小。为了证实胰岛素抵抗是否导致了观察到的高血压，我们研究了胰岛素增敏剂吡格列酮对饮用10%果糖溶液大鼠血压的影响。从12周龄开始，以10 mg/kg/天的剂量给大鼠施用吡格列酮4周后，血浆甘油三酯和胰岛素水平以及收缩压均下降，并且胰岛素引起的血糖降低恢复正常。这些结果表明，胰岛素抵抗是饮用果糖大鼠高血压发展的原因。
