Peek M J, Nelson-Piercy C, Manning R A, de Swiet M, Letsky E A
Institute of Obstetrics and Gynaecology, Queen Charlotte's Hospital, UK.
Br J Obstet Gynaecol. 1997 Sep;104(9):1084-6. doi: 10.1111/j.1471-0528.1997.tb12072.x.
This prospective cross-sectional (10 women on each occasion) and longitudinal (20 women) study investigated activated protein C (APC) ratio in normal pregnancy. The APC ratio was measured at booking, 20, 30 and 36 weeks of gestation, and compared with a sample of normal nonpregnant women. No significant difference was found between APC ratios for pregnant women at any gestation and those of the nonpregnant population in either the longitudinal or cross-sectional studies. There was a significant decrease in APC ratios throughout pregnancy, but in all but one case values remained within the normal nonpregnant range. The APC ratio can therefore be used as a screening test for the factor V Leiden mutation during pregnancy.
这项前瞻性横断面研究（每次10名女性）和纵向研究（20名女性）调查了正常妊娠中活化蛋白C（APC）比率。在妊娠登记时、妊娠20周、30周和36周测量APC比率，并与正常未怀孕女性样本进行比较。在纵向或横断面研究中，未发现任何孕周的孕妇与未怀孕人群的APC比率有显著差异。整个孕期APC比率显著下降，但除1例病例外，所有病例的值均保持在正常未怀孕范围内。因此，APC比率可作为孕期筛查因子V莱顿突变的一项检测。
