Cumming A M, Tait R C, Fildes S, Yoong A, Keeney S, Hay C R
University Department of Haematology, Manchester Royal Infirmary.
Br J Haematol. 1995 Jul;90(3):725-7. doi: 10.1111/j.1365-2141.1995.tb05610.x.
We measured activated protein C (APC) anticoagulant activity in 20 healthy women at 14-20, 28 and 36 weeks gestation, and at 1 d post-partum. Significant reductions in the mean APC sensitivity ratio (APC-SR) were observed at all stages of pregnancy studied compared with the mean APC-SR obtained for baseline measurements carried out at > 8 weeks post-partum. APC resistance was seen in 8/19 (42%) and in 11/20 (55%) women at 14-20 and 28 weeks gestation respectively. The development of resistance to APC may contribute to the increased risk of thrombosis during pregnancy.
我们测量了20名健康女性在妊娠14 - 20周、28周和36周以及产后1天时的活化蛋白C（APC）抗凝活性。与产后8周以上进行的基线测量所获得的平均APC敏感性比值（APC-SR）相比，在研究的妊娠各阶段均观察到平均APC-SR显著降低。分别在妊娠14 - 20周和28周时，19名女性中有8名（42%）和20名女性中有11名（55%）出现了APC抵抗。对APC产生抵抗可能会增加孕期血栓形成的风险。
