Peters W, Robinson B L
International Institute of Parasitology, St Albans, U.K.
Ann Trop Med Parasitol. 1997 Mar;91(2):141-5. doi: 10.1080/00034983.1997.11813123.
Two interactions of two potent blood schizontocides, pyronaridine and artemisinin, were assessed in mice infected with chloroquine-resistant Plasmodium yoelii ssp. NS or one of two lines derived from it, namely ART, which is resistant to artemisinin and SPN, which is resistant to pyronaridine. While the drug combination proved to be only additive in its action against P. yoelii ssp. NS, a marked potentiation between the two compounds was observed against the ART and SPN lines. The implications of the findings in terms of the impeding of drug resistance when these compounds are deployed for the treatment of multi-drug-resistant P. falciparum are discussed.
在感染氯喹抗性约氏疟原虫NS株或由其衍生的两个株系之一（即对青蒿素耐药的ART株和对咯萘啶耐药的SPN株）的小鼠中，评估了两种强效血液裂殖体杀灭剂咯萘啶和青蒿素的两种相互作用。虽然药物组合对约氏疟原虫NS株的作用仅为相加作用，但在针对ART株和SPN株时观察到这两种化合物之间有显著的增效作用。讨论了这些发现对于在使用这些化合物治疗多重耐药恶性疟原虫时阻碍耐药性产生方面的意义。
