Childs J A, Blair J L
DuPont Hospital for Children, Wilmington, Delaware, 19899, USA.
J Neurosci Nurs. 1997 Aug;29(4):244-8. doi: 10.1097/01376517-199708000-00005.
Case histories of autistic twins with absence seizures are presented. The boys had autistic features prior to the onset of seizures during their second year of life. By age 3 years, the twins were significantly delayed in the areas of socialization, communications and impulse control. Typical autistic features were pronounced, including perseverative, nonpurposeful and self-stimulatory behaviors; lack of symbolic play; poor eye contact; echolalic and noncommunicative speech; and unresponsiveness to disciplinary efforts. The absence seizures, although first observed by the parents early in the twins' second year, were not diagnosed until age 3 years 1 month. The seizures consisted of 50-60 staring spells per day. Both boys responded to valproic acid treatment with control of their seizures and with a dramatically accelerated rate of acquisition of both language and social skills. A possible causal relationship between autism and absence seizures in these children is explored.
本文介绍了患有失神发作的自闭症双胞胎的病历。这两个男孩在两岁癫痫发作开始前就有自闭症特征。到3岁时，这对双胞胎在社交、沟通和冲动控制方面明显滞后。典型的自闭症特征很明显，包括重复、无目的和自我刺激行为；缺乏象征性游戏；眼神交流差；模仿言语和非交流性言语；以及对纪律约束无反应。失神发作虽然最早由父母在双胞胎两岁时就观察到，但直到3岁1个月才被诊断出来。发作包括每天50 - 60次凝视发作。两个男孩对丙戊酸治疗有反应，癫痫发作得到控制，语言和社交技能的习得速度也显著加快。本文探讨了这些儿童自闭症与失神发作之间可能的因果关系。
