丙戊酸盐诱发的两名癫痫同卵双胞胎高氨血症。
Valproate-induced hyperammonaemia in two epileptic identical twins.
作者信息
Campostrini R, Zaccara G, Rossi L, Paganini M, Dorigotti A, Zappoli R
出版信息
J Neurol. 1985;232(3):167-8. doi: 10.1007/BF00313894.
PMID:3928828
Abstract
The cases of two epileptic identical twins are described, one of whom had presented an episode of valproate (VPA)-induced stupor associated with very high blood ammonia (NH3) concentrations. Both twins showed a similar marked increase of venous NH3 concentrations after the administration of a single loading dose of VPA (800 mg).
摘要
本文描述了一对癫痫同卵双胞胎的病例，其中一人曾出现与极高血氨（NH3）浓度相关的丙戊酸盐（VPA）诱导的木僵发作。在给予单次负荷剂量的VPA（800mg）后，双胞胎两人的静脉血氨浓度均出现了类似的显著升高。
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