Cox J S, Chapman R E, Walter P
Department of Biochemistry and Biophysics, University of California, School of Medicine, San Francisco 94143-0448, USA.
Mol Biol Cell. 1997 Sep;8(9):1805-14. doi: 10.1091/mbc.8.9.1805.
The endoplasmic reticulum (ER) is a multifunctional organelle responsible for production of both lumenal and membrane components of secretory pathway compartments. Secretory proteins are folded, processed, and sorted in the ER lumen and lipid synthesis occurs on the ER membrane itself. In the yeast Saccharomyces cerevisiae, synthesis of ER components is highly regulated: the ER-resident proteins by the unfolded protein response and membrane lipid synthesis by the inositol response. We demonstrate that these two responses are intimately linked, forming different branches of the same pathway. Furthermore, we present evidence indicating that this coordinate regulation plays a role in ER biogenesis.
内质网（ER）是一种多功能细胞器，负责分泌途径区室的腔内成分和膜成分的产生。分泌蛋白在内质网腔内折叠、加工和分选，脂质合成则发生在内质网膜本身。在酿酒酵母中，内质网成分的合成受到高度调控：内质网驻留蛋白通过未折叠蛋白反应进行调控，膜脂质合成通过肌醇反应进行调控。我们证明这两种反应紧密相连，形成了同一途径的不同分支。此外，我们提供的证据表明这种协调调控在内质网生物发生中发挥作用。
