Edge C J, Grieve A P, Gibbons N, O'Sullivan F, Bryson P
Hyperbaric Medical Centre, Tamar Science Park, Plymouth, England.
Undersea Hyperb Med. 1997 Sep;24(3):201-7.
A preliminary study to examine the hypothesis that the ability of well-controlled (defined as no hypoglycemic episodes within the last 12 mo., HbAlc < 9.0%, and none of the long-term complications of diabetes type I) diabetic scuba divers to control their serum glucose and dive without becoming hypoglycemic during a simulated dive to 27 meters of seawater in controlled environment is impaired. An open, controlled, crossover study compared blood glucose levels, hematocrits, and hematologic cell counts in a group of eight type I diabetic scuba divers to those from eight age- and sex-matched, normoglycemic control scuba divers. Each diver did one simulated dive and one control exercise on the surface on 2 consecutive days. The simulated dive was done to depth of 375 kPa in a hyperbaric chamber, the control exercise was done at ambient pressure. The order of the dive and the control exercise was randomized. No statistically significant differences were observed between serum glucose levels in the diabetic divers measured during the simulated dive to 375 kPa vs. the serum glucose levels in the diabetic divers measured during the control exercise at the same time points. All divers with type I diabetes remained free of symptoms and signs of hypoglycemia throughout the course of the trial, and no diabetic subject had a serum glucose less than 4 mmol/liter before the end of the trial. As the sample size was small, larger studies including subject with type II diabetes will be necessary to extend these results to the diabetic diving population at large. The authors conclude that, contrary to advice issued by most diving agencies to scuba divers, it may be safe to allow well-controlled subjects with type I diabetes with no long-term complications to undertake scuba diving, and that high partial pressures of oxygen do not seem to lower serum glucose levels significantly in the diabetic diver during the dive.
血糖控制良好(定义为过去12个月内无低血糖发作、糖化血红蛋白<9.0%且无I型糖尿病长期并发症)的糖尿病潜水员在受控环境下进行模拟27米海水潜水时,控制血清葡萄糖水平并避免低血糖的能力受损。一项开放性、对照、交叉研究比较了一组8名I型糖尿病潜水员与8名年龄和性别匹配的血糖正常的对照潜水员的血糖水平、血细胞比容和血液学细胞计数。每位潜水员在连续2天内进行一次模拟潜水和一次水面控制运动。模拟潜水在高压舱内进行至375 kPa深度,控制运动在常压下进行。潜水和控制运动的顺序是随机的。在模拟潜水至375 kPa期间测量的糖尿病潜水员血清葡萄糖水平与在相同时间点的控制运动期间测量的糖尿病潜水员血清葡萄糖水平之间未观察到统计学显著差异。在整个试验过程中,所有I型糖尿病潜水员均未出现低血糖症状和体征,且在试验结束前无糖尿病受试者的血清葡萄糖水平低于4 mmol/L。由于样本量较小,有必要进行更大规模的研究,包括纳入II型糖尿病患者,以便将这些结果推广到广大糖尿病潜水人群。作者得出结论,与大多数潜水机构给潜水员的建议相反,允许无长期并发症且血糖控制良好的I型糖尿病患者进行水肺潜水可能是安全的,并且在潜水过程中,高氧分压似乎不会显著降低糖尿病潜水员的血清葡萄糖水平。