精液中的纤连蛋白和透明质酸：与精子数量及典型形态百分比的关系

[Fibronectin and hyaluronic acid in seminal fluid: relationship with sperm count and percentage of typical forms].

作者信息

Laudat A, Guechot J, Foucault P, Giboudeau J, Palluel A M

机构信息

Centre Hospitalier Général de Chartres, Laboratoire de Biochimie-Biologie de la Reproduction, France.

出版信息

Pathol Biol (Paris). 1997 Jun;45(6):462-6.

PMID:9309260

Abstract

Two components of the extra cellular matrix, hyaluronic acid (HA) and fibronectin (Fbn), were assessed in the seminal fluids of 29 patients submitted for diagnosis of infertility. The concentrations of HA and Fbn were elevated in seminal plasma in comparison to their ranges of concentration in normal sera. No correlations were found between seminal Fbn and sperm count per ml and/or ejaculate, normal sperm cytology and multiple anomaly index (MAI). The concentrations of HA were negatively correlated with sperm count per ml (p < 0.01, r = -0.5) and ejaculate (p < 0.005, r = -0.5), and also with sperm cytology (p < 0.001, r = -0.6). A positive correlation was found between seminal concentrations of HA and MAI (p < 0.001, r = +0.7). It seems that high seminal HA concentrations were in relation with the bad results of sperm count and sperm cytology. These data suggest that spermatozoon could be implicated, in part, in the seminal HA metabolism.

摘要

在29例因不育前来诊断的患者的精液中，对细胞外基质的两个成分透明质酸（HA）和纤连蛋白（Fbn）进行了评估。与正常血清中的浓度范围相比，精浆中HA和Fbn的浓度升高。在精液Fbn与每毫升精子计数和/或射精量、正常精子细胞学以及多重异常指数（MAI）之间未发现相关性。HA的浓度与每毫升精子计数（p < 0.01，r = -0.5）和射精量（p < 0.005，r = -0.5）呈负相关，也与精子细胞学（p < 0.001，r = -0.6）呈负相关。在精液HA浓度与MAI之间发现正相关（p < 0.001，r = +0.7）。似乎精液中高浓度的HA与精子计数和精子细胞学的不良结果有关。这些数据表明，精子可能部分参与了精液中HA的代谢。