Harish Z, Rubinstein A, Golodner M, Elmaliah M, Mizrachi Y
Albert Einstein College of Medicine, Department of Pediatrics, Microbiology and Immunology, Bronx, New York 10461, USA.
Drugs Exp Clin Res. 1997;23(2):89-96.
In the current study we show that propolis, a non-toxic natural bee-hive product, suppresses HIV-1 replication and modulates in vitro immune responses. CEM cells were treated with propolis at nontoxic concentrations prior to or following infection with HIV-1. Propolis abolished syncytium formation at 4.5 micrograms/ml and inhibited it at lower doses in a concentration-dependent manner. Propolis decreased p24 antigen production by as much as 90-100% in a concentration-dependent manner. Furthermore, modulation of peripheral blood mononuclear cells (PBMCs) mitogenic responses upon the addition of propolis was noted, reducing the elevated responses to Concanavalin A (Con A) and enhancing suppressed mitogenic responses to pokeweed mitogen (PWM). In summary, propolis may constitute a non-toxic natural product with both anti HIV-1 and immunoregulatory effects.
在本研究中，我们表明蜂胶，一种无毒的天然蜂巢产品，可抑制HIV-1复制并调节体外免疫反应。在HIV-1感染之前或之后，用无毒浓度的蜂胶处理CEM细胞。蜂胶在4.5微克/毫升时消除了合胞体形成，并以浓度依赖的方式在较低剂量下抑制了合胞体形成。蜂胶以浓度依赖的方式使p24抗原产生减少多达90-100%。此外，还注意到添加蜂胶后对外周血单核细胞（PBMCs）有丝分裂反应的调节作用，降低了对刀豆球蛋白A（Con A）升高的反应，并增强了对商陆有丝分裂原（PWM）受抑制的有丝分裂反应。总之，蜂胶可能是一种具有抗HIV-1和免疫调节作用的无毒天然产品。
