Lidums I, Holloway R
Department of Gastrointestinal Medicine, Royal Adelaide Hospital, Australia.
Gastroenterol Clin North Am. 1997 Sep;26(3):519-31. doi: 10.1016/s0889-8553(05)70311-3.
Columnar-lined or Barrett's esophagus is a consequence of chronic gastroesophageal reflux and often represents severe reflux disease. Abnormalities of motility in Barrett's esophagus, therefore, are similar to those in patients with severe reflux esophagitis. Patients with Barrett's esophagus have a high prevalence of defective basal lower esophageal relaxations. Impaired esophageal peristalsis is more common than in patients with mild reflux esophagitis and comparable to patients with severe esophagitis. Systemic diseases associated with impaired esophageal motility may, as a consequence of chronic gastroesophageal reflux, predispose to Barrett's esophagus. In patients with Barrett's esophagus, there is little evidence that the esophageal motility abnormalities improve with either medical therapy or antireflux surgery.
柱状上皮化生或巴雷特食管是慢性胃食管反流的结果，通常代表严重的反流性疾病。因此，巴雷特食管的动力异常与重度反流性食管炎患者相似。巴雷特食管患者下食管基础松弛功能缺陷的发生率很高。食管蠕动受损比轻度反流性食管炎患者更常见，与重度食管炎患者相当。由于慢性胃食管反流，与食管动力受损相关的全身性疾病可能易患巴雷特食管。在巴雷特食管患者中，几乎没有证据表明药物治疗或抗反流手术能改善食管动力异常。
