Damien C J, Parsons J R, Prewett A B, Huismans F, Shors E C, Holmes R E
Laboratories for Orthopaedic Research, UMDNJ-New Jersey Medical School, Newark, USA.
J Biomater Appl. 1995 Jan;9(3):275-88. doi: 10.1177/088532829500900306.
Coralline hydroxyapatite (cHA) is an osteoconductive material currently being used as a bone graft substitute. Created by the hydrothermal conversion of the calcium carbonate skeleton of coral to hydroxyapatite, this material has a porous structure similar to cancellous bone. Addition of demineralized bone matrix (DBM) would conceivably create a composite with both osteoconductive and osteoinductive properties. This pilot study evaluated the healing of rabbit cranial defects that had been filled with cHA or cHA augmented with a DBM gel formed by adding glycerol to the DBM particulate. Data from these were then compared to unfilled defects from a previous study. Results indicated enhancement of new bone formation and an increase in the rate of healing in the defects filled with the cHA-DBM gel composite. Further studies are warranted.
珊瑚羟基磷灰石（cHA）是一种目前被用作骨移植替代物的骨传导材料。这种材料通过将珊瑚的碳酸钙骨架进行水热转化为羟基磷灰石而制成，具有类似于松质骨的多孔结构。加入脱矿骨基质（DBM）可以设想创造出一种兼具骨传导和骨诱导特性的复合材料。这项初步研究评估了用cHA或添加了通过向DBM颗粒中添加甘油形成的DBM凝胶增强的cHA填充的兔颅骨缺损的愈合情况。然后将这些数据与先前研究中的未填充缺损进行比较。结果表明，填充有cHA-DBM凝胶复合材料的缺损中，新骨形成增强，愈合速度加快。有必要进行进一步的研究。
