Flautre B, Descamps M, Delecourt C, Blary M C, Hardouin P
IR2B-62608 Berck/Mer Cedex, France.
J Mater Sci Mater Med. 2001 Aug;12(8):679-82. doi: 10.1023/a:1011256107282.
Hydroxyapatite (HA) porous ceramics are increasingly used in biomedical applications. Their physical characteristics, such as porous volume, require perfect control of the pore shape, as well as the number and the size of their interconnections. The aim of our study was to evaluate a new HA ceramic using polymethylmethacrylate microbeads (PMMA) as the porous agent. Four interconnection sizes (30, 60, 100 and 130 microm) with a 175-260 microm pore size and three pore sizes (175-260, 260-350 and 350-435 microm) for a 130 microm interconnection size were tested. Various HA implants were appraised by microscopic evaluation in a 4.6 x 10 mm rabbit femur cancellous bone defect 12 weeks after implantation. The best osteoconduction result was obtained in the center of the ceramic by means of a 130 microm interconnection size and a 175-260 microm mean pore size. Bone formation obtained within the pores was double that obtained in our previous study where naphtalen microbeads were used as the porous agents.
羟基磷灰石（HA）多孔陶瓷在生物医学应用中越来越受到青睐。其物理特性，如孔隙率，需要精确控制孔隙形状以及相互连通的数量和尺寸。我们研究的目的是评估一种以聚甲基丙烯酸甲酯微珠（PMMA）作为造孔剂的新型HA陶瓷。测试了四种相互连通尺寸（30、60、100和130微米），其孔径为175 - 260微米，以及针对130微米相互连通尺寸的三种孔径（175 - 260、260 - 350和350 - 435微米）。在植入12周后，通过对4.6×10毫米兔股骨松质骨缺损处的微观评估，对各种HA植入物进行了评价。通过130微米的相互连通尺寸和175 - 260微米的平均孔径，在陶瓷中心获得了最佳的骨传导效果。孔隙内的骨形成量是我们之前使用萘微珠作为造孔剂的研究中所获得骨形成量的两倍。
Zotero 插件