MacAuley D, McCrum E E, Stott G, Evans A E, Duly E, Trinick T R, Sweeney K, Boreham C A
Division of Epidemiology, Queen's University of Belfast, Royal Victoria Hospital, Ireland.
Med Sci Sports Exerc. 1997 Sep;29(9):1187-91. doi: 10.1097/00005768-199709000-00011.
The objective of this study was to investigate the relationship between physical fitness, lipids, and apolipoproteins in a cross-sectional study using a two-stage probability sample of the population of Northern Ireland. The main outcome measures were physical fitness using VO2max estimated by extrapolation from submaximal oxygen uptake while walking on a motor driven treadmill, and total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, HDL2 and HDL3, and Lp(a). There were no significant relationships with fitness, after adjustment for possible confounders, with the exception of a positive relationship with HDL2 in males (P < or = 0.01) and Lp(a) in females (P < or = 0.05). There was also a relationship between physical fitness and HDL:apo AI ratio in males and females after adjustment for possible confounders (P < or = 0.05). We concluded that there were few relationships between lipid parameters and physical fitness after adjustment for possible confounders. The relationship between physical fitness and Lp(a) in females suggests a benefit associated with physical fitness and the relationship between physical fitness and HDL:apo AI ratio was in keeping with improved HDL cholesterol transport.
本研究的目的是在一项横断面研究中，使用北爱尔兰人群的两阶段概率样本，调查体能、血脂和载脂蛋白之间的关系。主要结局指标包括：在电动跑步机上行走时通过次最大摄氧量外推法估算的最大摄氧量（VO₂max）来衡量的体能，以及总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、HDL₂、HDL₃和脂蛋白(a) [Lp(a)]。在对可能的混杂因素进行调整后，除男性中HDL₂呈正相关（P≤0.01）以及女性中Lp(a)呈正相关（P≤0.05）外，其他指标与体能均无显著关系。在对可能的混杂因素进行调整后，男性和女性的体能与HDL:载脂蛋白AI（apo AI）比值之间也存在关联（P≤0.05）。我们得出结论，在对可能的混杂因素进行调整后，血脂参数与体能之间的关系较少。女性体能与Lp(a)之间的关系表明体能有益，且体能与HDL:apo AI比值之间的关系与改善高密度脂蛋白胆固醇转运一致。
