Mboudjeka I, Zekeng L, Yamashita M, Takehisa J, Ido E, Miura T, Ohkura S, Ikeda M, Kaptue L, Hayami M
Laboratory of Pathogenic Virus, Kyoto University.
Jpn J Cancer Res. 1997 Jul;88(7):619-24. doi: 10.1111/j.1349-7006.1997.tb00427.x.
Our previous analysis of an HTLV-I isolate (CMR229) from a Cameroonian Pygmy demonstrated that the isolate is distinct from typical HTLV-Is of the "Central African group," which has a close similarity to HTLV-I-related simian viruses (STLV-I) in Africa. In this study, we analyzed six new HTLV-Is from Cameroon consisting of three isolates from the Pygmy and three from the Bantu to examine further the genetic features of HTLV-I in Cameroon, especially in the Pygmy. A phylogenetic tree based on the long terminal repeats (LTR) region showed that all the new HTLV-Is belong to the Central African group. On the other hand, an env-based analysis of CMR229 confirmed the previous finding derived from LTR-based analysis that CMR229 has a similarity to African STLV-Is, but is distinct from the typical Central African group of HTLV-I. This suggests that multiple interspecies transmissions from non-human primates to humans have occurred in Central Africa, resulting in the presence of two distinct HTLV-I strains in this area. In addition, it seems likely that the Pygmy harbors the heterogeneous HTLV-I strains from which the main HTLV-I population spread into the Bantu.
我们之前对一株来自喀麦隆俾格米人的人类嗜T淋巴细胞病毒I型（HTLV-I）分离株（CMR229）的分析表明，该分离株与“中非组”的典型HTLV-I不同，后者与非洲的HTLV-I相关猿猴病毒（STLV-I）极为相似。在本研究中，我们分析了来自喀麦隆的6株新的HTLV-I，其中包括3株来自俾格米人的分离株和3株来自班图人的分离株，以进一步研究喀麦隆，尤其是俾格米人中HTLV-I的遗传特征。基于长末端重复序列（LTR）区域构建的系统发育树表明，所有新的HTLV-I均属于中非组。另一方面，对CMR229基于env基因的分析证实了先前基于LTR分析得出的结果，即CMR229与非洲STLV-I具有相似性，但与典型的中非组HTLV-I不同。这表明在中非发生了多次从非人类灵长类动物到人类的种间传播，导致该地区存在两种不同的HTLV-I毒株。此外，俾格米人似乎携带了异质性的HTLV-I毒株，主要的HTLV-I群体由此传播到班图人中。
