来自美拉尼西亚的一种高度分化的人类I型嗜T细胞白血病（嗜淋巴细胞）病毒（HTLV-I）变异株的完整核苷酸序列：与其他地理区域的HTLV-I毒株的遗传及系统发育关系
Complete nucleotide sequence of a highly divergent human T-cell leukemia (lymphotropic) virus type I (HTLV-I) variant from melanesia: genetic and phylogenetic relationship to HTLV-I strains from other geographical regions.
作者信息
Gessain A, Boeri E, Yanagihara R, Gallo R C, Franchini G
机构信息
Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20892.
出版信息
J Virol. 1993 Feb;67(2):1015-23. doi: 10.1128/JVI.67.2.1015-1023.1993.
Abstract
The high prevalences of antibodies against human T-cell leukemia (lymphotropic) virus type I (HTLV-I) reported for remote populations in Papua New Guinea and the Solomon Islands and for some aboriginal populations in Australia have been verified by virus isolation. Limited genetic analysis of the transmembrane portion (gp21) of the envelope gene of these viruses indicates the existence of highly divergent HTLV-I strains in Melanesia. Here, we report the complete nucleotide sequence of an HTLV-I isolate (designated HTLV-IMEL5) from the Solomon Islands. The overall nucleotide divergence of HTLV-IMEL5 from the prototype HTLV-IATK was approximately 8.5%. The degree of variability in the amino acid sequences of structural genes ranged between 3 and 11% and was higher (8.5 to 25%) for the regulatory (tax and rex) genes and the other genes encoded by the pX region. Since HTLV-IMEL5 was as distantly related to HTLV-II as to the other known HTLV-I strains, it could not have arisen from a reocmbinational event involving HTLV-II but rather might be an example of independent viral evolution in this remote population. These data provide important insights and raise new questions about the origin and global dissemination of HTLV-I.
摘要
在巴布亚新几内亚和所罗门群岛的偏远人群以及澳大利亚的一些原住民中，针对I型人类T细胞白血病（嗜淋巴细胞）病毒（HTLV-I）的抗体高流行率已通过病毒分离得到证实。对这些病毒包膜基因跨膜部分（gp21）的有限基因分析表明，美拉尼西亚存在高度不同的HTLV-I毒株。在此，我们报告了一株来自所罗门群岛的HTLV-I分离株（命名为HTLV-IMEL5）的完整核苷酸序列。HTLV-IMEL5与原型HTLV-IATK的总体核苷酸差异约为8.5%。结构基因氨基酸序列的变异程度在3%至11%之间，而调节基因（tax和rex）以及pX区域编码的其他基因的变异程度更高（8.5%至25%）。由于HTLV-IMEL5与HTLV-II的亲缘关系与其他已知的HTLV-I毒株一样远，它不可能来自涉及HTLV-II的重组事件，而可能是这个偏远人群中病毒独立进化的一个例子。这些数据为HTLV-I的起源和全球传播提供了重要见解，并提出了新的问题。
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