3,4-苯并(s)芘与血清成分的温育：对肿瘤产生的影响。
Incubation of 3,4-benzo(s)pyrene with serum fractions: effect on tumor production.
作者信息
Stenbäck F, Curtis G, Rowland J, Ryan W
出版信息
J Cancer Res Clin Oncol. 1979 Oct;95(2):109-13. doi: 10.1007/BF00401004.
The effect on tumor formation in Swiss mice of incubation of 3,4-Benzo(a)pyrene [B(a)P]either with saline or saline containing serum, gamma-globulin or albumin (form mouse or rabbit) was investigated. A high incidence of sarcomas (80--100%) was obtained in Swiss mice by B(A)P incubated in vitro with rabbit serum, rabbit gamma-globulin, mouse serum, mouse gamma-globulin, and saline. A lower incidence (60--65%) was obtained with B(a)P incubated with mouse serum, mouse albumin, and rabbit albumin. The data suggest that binding of B(a)P to protein, particularly to albumin, significantly decreases the biological activity of B(a)P.
研究了3,4-苯并(a)芘[B(a)P]与生理盐水或含血清、γ球蛋白或白蛋白（来自小鼠或兔子）的生理盐水一起孵育对瑞士小鼠肿瘤形成的影响。通过将B(A)P与兔血清、兔γ球蛋白、小鼠血清、小鼠γ球蛋白和生理盐水在体外孵育，瑞士小鼠中肉瘤的发生率很高（80%-100%）。用B(a)P与小鼠血清、小鼠白蛋白和兔白蛋白孵育时，发生率较低（60%-65%）。数据表明，B(a)P与蛋白质，特别是与白蛋白的结合显著降低了B(a)P的生物活性。
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