Witting C, Witting U, Krieg V
J Cancer Res Clin Oncol. 1982;104(1-2):109-13. doi: 10.1007/BF00402059.
The possibility of a tumor-protective effect of selenium on the growth of benzpyrene-induced sarcoma was studied in an assay with Balb/c mice. The animals received 4 parts/10(6) selenium in their drinking water for 12 months prior to subcutaneous injection of benzpyrene to induce sarcomas. In contrast to unpretreated controls, the selenium-exposed animals developed significantly less and smaller tumors in a given time. These results are compared to those of other authors. Several mechanisms for selenium influence on benzpyrene metabolism are discussed.
在一项针对Balb/c小鼠的试验中，研究了硒对苯并芘诱导的肉瘤生长产生肿瘤保护作用的可能性。在皮下注射苯并芘诱导肉瘤之前，这些动物在其饮用水中摄入了百万分之四的硒，持续12个月。与未预处理的对照组相比，接触硒的动物在给定时间内形成的肿瘤明显更少、更小。将这些结果与其他作者的结果进行了比较。讨论了硒影响苯并芘代谢的几种机制。
