White R F, Feldman R G, Eviator I I, Jabre J F, Niles C A
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
Environ Res. 1997;73(1-2):113-24. doi: 10.1006/enrs.1997.3699.
This paper summarizes the findings gleaned from detailed clinical examinations of three groups of residents who were exposed to trichloroethylene in well water. Also summarized are diagnostic findings for peripheral neuropathy. A detailed description of the neuropsychological test results is included, as well as a summary of domain-specific findings and diagnostic outcomes. A high rate of cognitive deficits of the type seen in patients with central nervous system dysfunction attributable to solvent exposure was seen. In addition, there was a clear developmental trend: subjects who were younger at the time of TCE exposure showed deficits in a larger variety of cognitive realms than did subjects who had already reached adulthood by the time of exposure. In particular, language deficits were seen in the younger, but not older, exposed subjects.
本文总结了对三组饮用含三氯乙烯井水居民进行详细临床检查所获得的结果。同时总结了周围神经病变的诊断结果。文中包含了神经心理学测试结果的详细描述，以及特定领域的发现和诊断结果总结。观察到因接触溶剂导致中枢神经系统功能障碍的患者中出现的认知缺陷发生率较高。此外，存在明显的发展趋势：三氯乙烯接触时年龄较小的受试者比接触时已成年的受试者在更多认知领域存在缺陷。特别是，在年龄较小而非较大的接触受试者中发现了语言缺陷。
