Davis Stephanie I, Laszlo Pallos L, Wu Jennifer Q, Sapp James H, Cusack Caroline
Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, USA.
Arch Environ Occup Health. 2005 May-Jun;60(3):130-9. doi: 10.3200/AEOH.60.3.130-139.
The National Exposure Registry of the Agency for Toxic Substances and Disease Registry (ATSDR) uses standard methods to study human exposure in four chemical subregistries: trichloroethylene (TCE), dioxin, benzene, and trichloroethane. The TCE Subregistry includes a baseline cohort of 4006 white registrants with drinking water exposure in Michigan, Indiana, Illinois, Pennsylvania, and Arizona. Between 3 and 6 follow-ups per site were conducted from 1989 to 2000, after baseline. Standardized morbidity ratios, controlling for age and sex, compared prevalences of 16 general health conditions in the subregistry with aggregated national estimates from the 1989-1994 National Health Interview surveys. Excess cases of dermatologic, hematologic, or hepatic disorders and strokes persisted over the lifetime of the registry. Persistent excess urinary tract disorders are likely caused by a systematic bias. This review of first-generation methods may be used to strengthen future exposure registries.
美国有毒物质与疾病登记署（ATSDR）的国家暴露登记处采用标准方法，在四个化学子登记处研究人类暴露情况：三氯乙烯（TCE）、二恶英、苯和三氯乙烷。TCE子登记处包括4006名在密歇根州、印第安纳州、伊利诺伊州、宾夕法尼亚州和亚利桑那州有饮用水暴露史的白人登记者组成的基线队列。在基线之后，从1989年到2000年，每个地点进行了3至6次随访。在控制年龄和性别的情况下，标准化发病比将该子登记处16种一般健康状况的患病率与1989 - 1994年国家健康访谈调查的全国汇总估计值进行了比较。在登记处的整个存续期间，皮肤病、血液学或肝脏疾病以及中风的超额病例一直存在。持续性泌尿系统疾病超额可能是由系统性偏差导致的。对第一代方法的这项综述可用于加强未来的暴露登记处。
