口服菊粉对链脲佐菌素诱导糖尿病大鼠肝脏组织中果糖-2,6-二磷酸水平的影响

[Effect of oral inulin administration on the fructose 2,6-biphosphate level in the liver tissue of rats with streptozocin diabetes].

作者信息

Guseva D A, Gorodetskiĭ V K, Kraevoĭ S A, Markova M S, Tsyganova T B

出版信息

Vopr Med Khim. 1997 Jul-Aug;43(4):247-55.

Abstract

The influence of oral inulin administration on glucose and fructose content in blood, glucose and ketone bodies in urine, and fructose-2,6-diphosphate content in liver was investigated in rats with streptozotocin diabetes. Short-term administration (during 5-6 days) of 0.5% inulin solution caused three-fold increase of blood fructose compared with control, normalisation of blood glucose and disappearance of glucose- and ketoneuria. The level of fructose-2,6-di-phosphate in liver increased to the control level. Inulin administration during 12 days caused five-fold increase of blood fructose compares with control, glucose level increased up to the level of uncurred diabetes (22 mmol/1), glucose- and ketoneuria appeared. The content of fructose-2,6-diphosphate in the liver decreased to diabetic level.

摘要

在链脲佐菌素诱导的糖尿病大鼠中，研究了口服菊粉对血液中葡萄糖和果糖含量、尿液中葡萄糖和酮体以及肝脏中果糖-2,6-二磷酸含量的影响。短期（5-6天）给予0.5%菊粉溶液，与对照组相比，血液果糖增加了两倍，血糖恢复正常，葡萄糖尿和酮尿消失。肝脏中果糖-2,6-二磷酸水平升至对照水平。连续12天给予菊粉，与对照组相比，血液果糖增加了五倍，血糖水平升至未治疗糖尿病的水平（22 mmol/1），出现葡萄糖尿和酮尿。肝脏中果糖-2,6-二磷酸含量降至糖尿病水平。