Golubev M A, Markova M S, Stvolinskaia N S
Vopr Med Khim. 1993 Nov-Dec;39(6):13-5.
Content of fructose-2,6-bisphosphate was drastically decreased (about 5-fold) in hepatocyte suspension obtained from rats with streptozotocin-induced diabetes, as compared with that of control animals. At the same time, activity of fructose-1,6-bisphosphatase was increased 2-fold in these hepatocytes. Incubation mixture of the hepatocytes from the diabetes impaired animals contained only low amounts of lactate.
与对照动物相比，从链脲佐菌素诱导的糖尿病大鼠获得的肝细胞悬液中果糖-2,6-二磷酸的含量急剧下降（约5倍）。同时，这些肝细胞中果糖-1,6-二磷酸酶的活性增加了2倍。糖尿病受损动物的肝细胞孵育混合物中仅含有少量乳酸。
