Baccelli G, Reggiani P, Mattioli A, Corbellini E, Garducci S, Catalano M, Omboni S
Centro di Fisiologia Clinica e Ipertensione, Policlinico di Milano, Italy.
Angiology. 1997 Sep;48(9):795-803. doi: 10.1177/000331979704800906.
The effects of arteriosclerosis obliterans on the hemodynamic changes that occur during walking are largely unknown. For this reason, the authors measured blood pressure by transducer from the posterior tibial artery and vein at both ankles in 23 patients with arteriosclerosis obliterans of different severity and at the left ankle in 8 normal subjects. Radial artery pressure was also measured, and the differences between mean radial and ankle arterial pressures (pressure gradient) and between mean arterial and venous ankle pressures (foot perfusion pressure) were calculated. All measurements were made simultaneously and continuously during standing, treadmill walking at five different speeds, and during recovery. Compared with the normal subjects, the patients exhibited a greater pressure gradient and lower ankle arterial pressure and foot perfusion pressure at rest. During walking and recovery these intergroup hemodynamic differences were markedly enhanced, and ankle venous pressure was lower in the patients than in the normal subjects. In the patients the hemodynamic pattern depended on disease severity at rest and on both disease severity and walking speed during walking and recovery.
闭塞性动脉硬化对行走过程中发生的血流动力学变化的影响在很大程度上尚不清楚。因此，作者使用传感器测量了23例不同严重程度的闭塞性动脉硬化患者双踝后胫动脉和静脉的血压，以及8名正常受试者左踝的血压。还测量了桡动脉血压，并计算了平均桡动脉与踝动脉血压之间的差异（压力梯度）以及平均动脉与踝静脉血压之间的差异（足部灌注压）。所有测量均在站立、以五种不同速度在跑步机上行走以及恢复过程中同时连续进行。与正常受试者相比，患者在静息时表现出更大的压力梯度、更低的踝动脉血压和足部灌注压。在行走和恢复过程中，这些组间血流动力学差异明显增强，并且患者的踝静脉血压低于正常受试者。在患者中，血流动力学模式取决于静息时的疾病严重程度以及行走和恢复过程中的疾病严重程度和行走速度。
