Safar M E, Totomoukouo J J, Asmar R A, Laurent S M
Arteriosclerosis. 1987 May-Jun;7(3):232-7. doi: 10.1161/01.atv.7.3.232.
Brachial blood pressure, ankle systolic pressure, calf blood flow before and after postocclusive reactive hyperemia, and treadmill exercise results were determined in 16 patients with arteriosclerosis obliterans disease (AOD) of the lower limbs. These values were compared with values from 16 controls matched for age and sex. For the same mean arterial pressure in controls, pulse pressure was significantly higher and resting calf blood flow, slightly lower in patients with AOD. Resting calf blood flow was positively correlated with mean arterial pressure and pulse pressure in patients with AOD but not in controls. In AOD patients, reduced walking distance was strongly and positively correlated with "vascular bed reserve" expressed as the ratio between peak blood flow after postocclusive reactive hyperemia and resting calf blood flow. Correlation studies indicated that the higher the pulse pressure, the more reduced the walking distance and the more altered the vascular bed reserve. The study provided evidence that: increased pulse pressure, rather than increased mean arterial pressure, is a characteristic feature of patients with AOD, and the pulsatile component of blood pressure, which reflects the alteration of the buffering function of large arteries, might influence the reductions in walking distance and vascular bed reserve observed in patients with AOD.
对16例下肢动脉硬化闭塞症（AOD）患者测定了肱动脉血压、踝部收缩压、闭塞后反应性充血前后的小腿血流量以及跑步机运动结果。将这些值与16名年龄和性别匹配的对照组的值进行比较。在对照组平均动脉压相同的情况下，AOD患者的脉压显著更高，静息小腿血流量略低。AOD患者的静息小腿血流量与平均动脉压和脉压呈正相关，而对照组则不然。在AOD患者中，步行距离缩短与以闭塞后反应性充血后峰值血流量与静息小腿血流量之比表示的“血管床储备”呈强正相关。相关性研究表明，脉压越高，步行距离缩短越明显，血管床储备改变越大。该研究提供的证据表明：脉压升高而非平均动脉压升高是AOD患者的一个特征，反映大动脉缓冲功能改变的血压搏动成分可能会影响AOD患者观察到的步行距离缩短和血管床储备降低。
