Taylor C A, Hendley J O, Greer K E, Gwaltney J M
Arch Dermatol. 1977 Nov;113(11):1550-2.
The efficacy of topical chloroform treatment of herpes labialis (HL) was evaluated in 50 patients with culture-verified HL. Treatment was begun within 48 hours of lesion onset, with either chloroform or camphor-in-oil placebo applied locally once a day for three days. Patients were observed daily by one investigator who also cultured and photographed the lesions. The photographs were evaluated by two other investigators. By direct observation, the time for scab formation was significantly less in the group treated with chloroform (P less than .01). No difference in time to healing was noted. Blind evaluation of the serial photographs showed a trend for more rapid scab formation and healing in patients treated with chloroform, but the differences were not significant. The minimal benefit derived from topical chloroform therapy of HL does not appear sufficient to recommend its routine use.
对50例经培养证实为唇疱疹（HL）的患者评估了局部用氯仿治疗HL的疗效。在病损发作48小时内开始治疗，每天局部应用一次氯仿或樟脑油安慰剂，共三天。由一名研究者每日对患者进行观察，该研究者还对病损进行培养和拍照。照片由另外两名研究者进行评估。通过直接观察，氯仿治疗组结痂形成时间显著缩短（P<0.01）。愈合时间未见差异。对系列照片的盲法评估显示，氯仿治疗的患者有结痂形成和愈合更快的趋势，但差异不显著。局部用氯仿治疗HL所获得的最小益处似乎不足以推荐其常规使用。
