Lorenz Veronique, Karanis Panagiotis
Panagiotis Karanis, Medical and Molecular Parasitology Laboratory, University of Cologne, Medical School, Center of Anatomy, Institute II, Cologne, Germany.
Asian Pac J Trop Biomed. 2011 Jan;1(1):74-8. doi: 10.1016/S2221-1691(11)60072-5.
The current status of malaria vaccine approaches has the background of a long and arduous path of malaria disease control and vaccine development. Here, we critically review with regard to unilateral interventional approaches and highlight the impact of socioeconomic elements of malaria endemicity. The necessity of re-energizing basic research of malaria life-cycle and Plasmodium developmental biology to provide the basis for promising and cost-effective vaccine approaches and to reach eradication goals is more urgent than previously believed. We closely analyse the flaws of various vaccine approaches, outline future directions and challenges that still face us and conclude that the focus of the field must be shifted to the basic research efforts including findings on the skin stage of infection. We also reflect on economic factors of vaccine development and the impact of public perception when it comes to vaccine uptake.
疟疾疫苗研发进展的现状有着疟疾疾病控制和疫苗研发漫长而艰巨历程的背景。在此，我们批判性地审视了单方面的干预方法，并强调了疟疾流行地区社会经济因素的影响。重振疟疾生命周期和疟原虫发育生物学基础研究的必要性比以往认为的更为迫切，这可为有前景且具成本效益的疫苗研发方法提供依据，并实现根除目标。我们仔细分析了各种疫苗研发方法的缺陷，概述了我们仍面临的未来方向和挑战，并得出结论，该领域的重点必须转向基础研究工作，包括感染皮肤阶段的研究成果。我们还思考了疫苗研发的经济因素以及公众认知对疫苗接种的影响。
