Murakami M, Tatsuma N, Tsugu H, Ambo K, Tsuchiya M, Yamamoto M, Yamauchi K
Department of Pediatrics, Nippon Medical School Hospital, Tokyo, Japan.
Acta Paediatr Jpn. 1997 Aug;39(4):413-5. doi: 10.1111/j.1442-200x.1997.tb03608.x.
Abnormalities were detected in 2669 of 326,257 elementary and junior high school children (169,856 males and 156,401 females) who were screened at school for urinary abnormalities. Serum complement (C3) level was measured in all 2669 children having urinary abnormalities (811 males, 1856 females). Three had a serum C3 level that was more than three standard deviations below the mean value. Type I membranoproliferative glomerulonephritis (MPGN) was diagnosed on histological examination in one of these three children, while the other two did not undergo renal biopsy because they had serum C3 levels of 40 and 44 mg/dL, respectively, and because their urinary abnormalities were transient. It was considered that there is not much significance in testing the serum complement in the urine screening done at school and the cost/benefit ratio is low. The results appeared to reflect the frequency of persistent hypocomplementemic MPGN in Japan in recent years.
在326257名接受学校尿液异常筛查的中小学生（169856名男生和156401名女生）中，有2669人检测出异常。对所有2669名有尿液异常的儿童（811名男性，1856名女性）进行了血清补体（C3）水平检测。其中3人的血清C3水平比平均值低三个标准差以上。这三名儿童中的一名经组织学检查诊断为I型膜增生性肾小球肾炎（MPGN），另外两名儿童未进行肾活检，因为他们的血清C3水平分别为40和44mg/dL，且尿液异常是暂时的。研究认为，在学校进行的尿液筛查中检测血清补体意义不大，成本效益比很低。结果似乎反映了近年来日本持续性低补体血症性MPGN的发病频率。
