York B, Lei K, West D B
Diabetes and Metabolism Section, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA.
Mamm Genome. 1997 Oct;8(10):726-30. doi: 10.1007/s003359900554.
In this study we describe the contribution of matrilineal and patrilineal effects on the adiposity, body weight, and on the weights of individual fat pads in F2 male mice derived from an SWR/J x AKR/J cross. AKR/J mice become obese after 12 weeks on a high-fat diet, whereas SWR/J mice remain relatively lean. Here we report that mice with AKR maternal and AKR paternal grandmothers have significantly larger epidydimal and retroperitoneal fat pads than those with SWR maternal and paternal grandmothers. However, grandparental strain had no effect on the overall adiposity (AI) or the weights of the inguinal, subcutaneous or mesenteric fat pads. The strain of the paternal grandparents had a small but significant effect on body weight. These effects can be attributed to in utero effects, imprinting effects, cytoplasmic and/or Y chromosome transmission of factors controlling body fat. We also describe the presence of a quantitative trait locus (QTL) on Chromosome X, close to DXMit174, which is linked to adiposity, body weight, and to the weights of the individual fat depots. However, this QTL is not responsible for the grandparental strain effects described above.
在本研究中，我们描述了母系和父系效应对于由SWR/J与AKR/J杂交产生的F2雄性小鼠的肥胖程度、体重以及各个脂肪垫重量的影响。AKR/J小鼠在高脂饮食12周后会变得肥胖，而SWR/J小鼠则相对较瘦。在此我们报告，具有AKR母系和父系祖母的小鼠，其附睾和腹膜后脂肪垫明显大于具有SWR母系和父系祖母的小鼠。然而，祖父母的品系对总体肥胖程度（AI）或腹股沟、皮下或肠系膜脂肪垫的重量没有影响。父系祖父母的品系对体重有微小但显著的影响。这些效应可归因于子宫内效应、印记效应、控制体脂的因子的细胞质和/或Y染色体传递。我们还描述了X染色体上靠近DXMit174的一个数量性状基因座（QTL）的存在，它与肥胖程度、体重以及各个脂肪储存部位的重量相关。然而，这个QTL并不导致上述祖父母品系效应。
