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胶质细胞外基质:发育和再生中轴突生长的边界

Glial cell extracellular matrix: boundaries for axon growth in development and regeneration.

作者信息

Fitch M T, Silver J

机构信息

Department of Neurosciences, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.

出版信息

Cell Tissue Res. 1997 Nov;290(2):379-84. doi: 10.1007/s004410050944.

DOI:10.1007/s004410050944
PMID:9321701
Abstract

Astrocytes and other glia in the central nervous system are now thought to produce molecules that negatively modulate axon growth, thereby influencing axon pathfinding in both development and regeneration. The relevant evidence for glial cell boundaries and the inhibitory molecules present in these extracellular matrix structures is discussed in this minireview.

摘要

目前认为,中枢神经系统中的星形胶质细胞和其他神经胶质细胞会产生对轴突生长具有负调节作用的分子,从而影响发育和再生过程中的轴突导向。本综述讨论了神经胶质细胞边界以及这些细胞外基质结构中存在的抑制性分子的相关证据。

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