Klijanienko J, El-Naggar A K, Servois V, Rodriguez J, Validire P, Vielh P
Department of Pathology, Institut Curie, Paris, France.
Head Neck. 1997 Oct;19(7):629-33. doi: 10.1002/(sici)1097-0347(199710)19:7<629::aid-hed11>3.0.co;2-y.
It has been suggested that metastasizing pleomorphic adenomas may represent unrecognized malignancy.
The cytologic and clinical characteristics of two metastasizing pleomorphic adenomas diagnosed by fine-needle sampling are reported.
Both showed malignant evolution: the primary tumors arose from the palate and the parotid salivary glands, respectively. Metastases occurred simultaneously with local recurrence in the first patient and after a second local recurrence in the second patient. Both patients were treated by surgery and radiotherapy but died of disseminated disease 8 and 4 years after initial diagnosis. No histologic evidence of malignancy was observed on cytology smears or histology sections in either case.
Clinically, our cases support the hypothesis that metastasizing pleomorphic adenomas represent unrecognized malignancy, because the biologic course of two tumors led to unequivocally lethal outcome.
有人提出转移性多形性腺瘤可能代表未被认识的恶性肿瘤。
报告了两例经细针穿刺诊断的转移性多形性腺瘤的细胞学和临床特征。
两例均显示恶性进展：原发肿瘤分别起源于腭部和腮腺。第一例患者转移与局部复发同时发生，第二例患者在第二次局部复发后发生转移。两名患者均接受了手术和放疗，但在初次诊断后8年和4年死于播散性疾病。两例病例的细胞学涂片或组织学切片均未观察到恶性肿瘤的组织学证据。
临床上，我们的病例支持转移性多形性腺瘤代表未被认识的恶性肿瘤这一假说，因为这两个肿瘤的生物学过程导致了明确的致命结局。
