Roitman S E, Keefe R S, Harvey P D, Siever L J, Mohs R C
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA.
Schizophr Res. 1997 Aug 29;26(2-3):139-46. doi: 10.1016/s0920-9964(97)00044-3.
Thirty patients with a DSM-III-R diagnosis of schizophrenia were assessed for severity of schizophrenic symptoms using the Brief Psychiatric Rating Scale (BPRS) and were tested on a Continuous Performance Test (CPT) and a smooth pursuit eye tracking task. Negative symptoms were significantly correlated with eye tracking impairment (r = 0.43, p < 0.01) and CPT deficits (r = 0.67, p < 0.001), but performance on neither task was correlated with positive symptoms. CPT performance and eye tracking performance were modestly correlated with each other (r = 0.39, p < 0.01) and CPT performance was found to be a stronger predictor of negative symptoms than eye tracking performance. These data indicate that neurocognitive markers of vulnerability to schizophrenia are associated with negative rather than positive symptoms.
对30名符合《精神疾病诊断与统计手册第三版修订本》（DSM-III-R）精神分裂症诊断标准的患者，使用简明精神病评定量表（BPRS）评估其精神分裂症症状的严重程度，并对他们进行了连续作业测试（CPT）和平滑跟踪眼球运动任务测试。阴性症状与眼球运动跟踪障碍显著相关（r = 0.43，p < 0.01）以及与连续作业测试缺陷显著相关（r = 0.67，p < 0.001），但两项任务的表现均与阳性症状无关。连续作业测试表现与眼球运动跟踪表现之间存在适度相关性（r = 0.39，p < 0.01），并且发现连续作业测试表现比眼球运动跟踪表现更能有力地预测阴性症状。这些数据表明，精神分裂症易感性的神经认知标志物与阴性症状而非阳性症状相关。
