Casey R, Li W W
Charles R. Drew University of Medicine and Science, University of California, Los Angeles, USA.
Am J Ophthalmol. 1997 Oct;124(4):521-9. doi: 10.1016/s0002-9394(14)70868-2.
To provide an overview of the cellular and molecular factors involved in ocular angiogenesis.
A literature search and review encompassing a broad range of medical and basic science disciplines was undertaken to survey contemporary insights into the mechanisms of angiogenic stimulation and inhibition.
Ocular angiogenesis is a complex pathophysiologic process. Factors have been isolated that play key roles in the regulation of angiogenesis. The influence of stimulating growth factors is counterbalanced by a number of antiproliferative agents. The net result of these opposing factors on the vascular endothelial cell determines the outcome of angiogenesis homeostasis. Both endogenous and synthetic molecules can regulate ocular angiogenesis.
The isolation and synthesis of molecular regulators of angiogenesis has enhanced our understanding of this process. Clinical trials are underway to determine the efficacy of these agents in controlling pathologic angiogenesis, including that in ocular disease.
概述眼部血管生成中涉及的细胞和分子因素。
进行了一项涵盖广泛医学和基础科学学科的文献检索与综述，以审视对血管生成刺激和抑制机制的当代见解。
眼部血管生成是一个复杂的病理生理过程。已分离出在血管生成调节中起关键作用的因素。刺激生长因子的影响被多种抗增殖剂所抵消。这些相互对立的因素对血管内皮细胞的最终作用决定了血管生成稳态的结果。内源性和合成分子均可调节眼部血管生成。
血管生成分子调节剂的分离与合成增进了我们对这一过程的理解。目前正在进行临床试验，以确定这些药物在控制病理性血管生成（包括眼部疾病中的血管生成）方面的疗效。
