Rihs H P, Barbalho-Krölls T, Huber H, Baur X
Institute of Occupational Medicine (BGFA), Ruhr-University Bochum, Germany.
Am J Ind Med. 1997 Nov;32(5):522-7. doi: 10.1002/(sici)1097-0274(199711)32:5<522::aid-ajim13>3.0.co;2-4.
Isocyanates are one of the main causes of occupational asthma. The aim of this investigation was to study the possible genetic background of isocyanate-induced asthma under consideration of the atopy status and different lung function parameters. We investigated the human leukocyte antigen (HLA) genes DRB1,3,4,5, DQB1, and DQA1 in 55 isocyanate-exposed patients with workplace-related dyspnea (32 asthmatics, 23 nonasthmatics) and 90 nonexposed controls. In contrast to other studies, we found no significant differences for any HLA class II allele tested in our study group. Furthermore, no significant differences concerning the aspartic amino acid residue 57 of DQB1 was observed. Therefore, we are unable to confirm an involvement of a specific HLA class II allele or DQB1-Asp57 in conferring susceptibility to isocyanate asthma in our study group.
异氰酸酯是职业性哮喘的主要病因之一。本研究的目的是在考虑特应性状态和不同肺功能参数的情况下，研究异氰酸酯诱发哮喘的可能遗传背景。我们调查了55名有工作场所相关呼吸困难的异氰酸酯暴露患者（32名哮喘患者，23名非哮喘患者）和90名未暴露对照者的人类白细胞抗原（HLA）基因DRB1、3、4、5、DQB1和DQA1。与其他研究不同，我们在研究组中未发现所检测的任何HLA II类等位基因有显著差异。此外，未观察到DQB1天冬氨酸残基57有显著差异。因此，我们无法证实特定的HLA II类等位基因或DQB1 - Asp57在我们的研究组中赋予异氰酸酯哮喘易感性方面的作用。
