Yucesoy Berran, Johnson Victor J, Lummus Zana L, Kashon Michael L, Rao Marepalli, Bannerman-Thompson Hansen, Frye Bonnie, Wang Wei, Gautrin Denyse, Cartier André, Boulet Louis-Philippe, Sastre Joaquin, Quirce Santiago, Tarlo Susan M, Germolec Dori R, Luster Michael I, Bernstein David I
From the Health Effects Laboratory Division (Drs Yucesoy and Kashon, Ms Frye, and Ms Wang) NIOSH/CDC, Morgantown, WVa; BRT-Burleson Research Technologies (Dr Johnson), Morrisville, NC; Division of Immunology, Allergy and Rheumatology, Department of Medicine (Drs Yucesoy, Lummus, and Bernstein) and Department of Environmental Health (Drs Rao and Bannerman-Thompson), University of Cincinnati, Ohio; Hôpital du Sacré-Cœur de Montréal (Drs Gautrin and Cartier), Université de Montréal; Hôpital Laval (Dr Boulet), Université Laval, Sainte-Foy, Québec, Canada; Department of Allergy (Dr Sastre), Fundación Jiménez Díaz and CIBER de Enfermedades Respiratorias CIBERES; Department of Allergy (Dr Quirce), Hospital La Paz-IdiPAZ and CIBER de Enfermedades Respiratorias CIBERES, Madrid, Spain; Department of Medicine (Dr Tarlo), University of Toronto, Ontario, Canada; Toxicology Branch (Dr Germolec), DNTP/NIEHS, Research Triangle Park, NC; and School of Public Health (Dr Luster), West Virginia University, Morgantown.
J Occup Environ Med. 2014 Apr;56(4):382-7. doi: 10.1097/JOM.0000000000000138.
To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA).
The study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels.
The HLA-E rs1573294 and HLA-DPB1 rs928976 SNPs were associated with an increased risk of DA under dominant (odds ratio [OR], 6.27; 95% confidence interval [CI], 2.37 to 16.6; OR, 2.79, 95% CI, 0.99 to 7.81, respectively) and recessive genetic models (OR, 6.27, 95% CI, 1.63 to 24.13; OR, 10.10, 95% CI, 3.16 to 32.33, respectively). The HLA-B rs1811197, HLA-DOA rs3128935, and HLA-DQA2 rs7773955 SNPs conferred an increased risk of DA in a dominant model (OR, 7.64, 95% CI, 2.25 to 26.00; OR, 19.69, 95% CI, 2.89 to 135.25; OR, 8.43, 95% CI, 3.03 to 23.48, respectively).
These results suggest that genetic variations within HLA genes play a role in DA risk.
研究主要组织相容性复合体中单个核苷酸多态性（SNP）与二异氰酸酯诱导的哮喘（DA）易感性之间的关联。
研究人群包括140名接触二异氰酸酯的工人。使用Illumina GoldenGate主要组织相容性复合体面板进行基因分型。
在显性遗传模型（优势比[OR]，6.27；95%置信区间[CI]，2.37至16.6；OR，2.79，95%CI，0.99至7.81）和隐性遗传模型（OR，6.27，95%CI，1.63至24.13；OR，10.10，95%CI，3.16至32.33）下，HLA-E rs1573294和HLA-DPB1 rs928976 SNP与DA风险增加相关。HLA-B rs1811197、HLA-DOA rs3128935和HLA-DQA2 rs7773955 SNP在显性模型中增加了DA风险（OR分别为7.64，95%CI，2.25至26.00；OR，19.69，95%CI，2.89至135.25；OR，8.43，95%CI，3.03至23.48）。
这些结果表明HLA基因内的遗传变异在DA风险中起作用。
