用一种新型抗惊厥药（氯硝西泮）治疗三叉神经痛。
Treatment of tic douloureux with a new anticonvulsant (clonazepam).
作者信息
Court J E, Kase C S
出版信息
J Neurol Neurosurg Psychiatry. 1976 Mar;39(3):297-9. doi: 10.1136/jnnp.39.3.297.
Twenty-five patients affected by 30 episodes of tic douloureux were treated with a new anticonvulsant, clonazepam. In 40% there was complete control of the neuralgia and an additional 23.3% were significantly helped by the drug. Sixteen patients had previously been resistant to carbamazepine, and eight of them were completely and one partially relieved by clonazepam. The side-effects, somnolence and unsteadiness of gait, were present to some extent in 80 and 88% of the cases respectively, being severe in about half of them. It is concluded that clonazepam can be considered as a second choice for the treatment of this condition, after proven failure with carbamazepine. Possible mechanisms of action are discussed.
25名患有30次三叉神经痛发作的患者接受了一种新型抗惊厥药物氯硝西泮的治疗。40%的患者神经痛得到完全控制，另有23.3%的患者从该药物中显著获益。16名患者之前对卡马西平耐药，其中8名患者疼痛完全缓解，1名部分缓解。副作用嗜睡和步态不稳分别在80%和88%的病例中不同程度出现，约一半病例较为严重。得出的结论是，在卡马西平治疗失败后，氯硝西泮可被视为治疗该疾病的第二选择。文中还讨论了可能的作用机制。
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