Collins A, Cadet J, Epe B, Gedik C
Rowett Research Institute, Bucksburn, Aberdeen, UK.
Carcinogenesis. 1997 Sep;18(9):1833-6. doi: 10.1093/carcin/18.9.1833.
Oxidative DNA damage is widely believed to play a role in cancer aetiology. It is therefore important to be able to assess it, both as an index of cancer risk, and in experiments to test agents with a potential to reduce oxidative damage, such as dietary antioxidants. However, there is an alarming discordance in estimates of concentrations of oxidative damage in human DNA, largely attributable to the kind of method used to measure it. A meeting was held recently at the Rowett Research Institute in Aberdeen to address this problem.
人们普遍认为氧化DNA损伤在癌症病因学中起作用。因此，能够对其进行评估非常重要，既可以作为癌症风险的指标，也可以用于测试具有降低氧化损伤潜力的物质（如膳食抗氧化剂）的实验中。然而，在人类DNA中氧化损伤浓度的估计值上存在令人担忧的不一致，这在很大程度上归因于用于测量它的方法类型。最近在阿伯丁的罗维特研究所召开了一次会议来解决这个问题。
