Olin J M, Smith T J, Talcott M R
Division of Comparative Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
Am J Vet Res. 1997 Oct;58(10):1065-9.
To evaluate instrument placement and accuracy of indirect physiologic monitoring techniques in anesthetized domestic ferrets.
10 healthy adult female ferrets (Mustela putorius furo).
Direct arterial blood pressure measurement and arterial blood sample collection were performed in ferrets. A pulse oximeter probe was clipped to a forefoot or hind foot; an airway adaptor for capnography was attached to the endotracheal tube; and a sphygmomanometer cuff and Doppler flow probe were positioned on the tail. Isoflurane and nitrous oxide concentrations were varied to induce episodes of hypotension or hypoxia, respectively. Aforementioned noninvasive techniques were compared with direct methods of arterial blood gas analysis, hemoximetry, and arterial blood pressure measurement. Simultaneously obtained direct and indirect measurements were statistically evaluated for mean and SD of the differences, and SEM, and subjectively, for ease of use and relevance to the clinical situation.
Values obtained from pulse oximetry were closely related to oxygen saturation measured by blood gas analysis (O2sat). The mean (+/- SD) difference for all results was -0.49 (+/- -4.09)%. The most precise measurements were obtained when O2sat was between 90 and 100%. Capnography measurements varied between ranges. The most accurate measurements were obtained when PaCO2 was < 25 mm of Hg, when the mean difference was 1.6 (+/- -3.01) mm of Hg. Indirect blood pressure measurement consistently underestimated the direct blood pressure value.
Pulse oximetry is a convenient and accurate method for monitoring oxygen saturation in domestic ferrets. Capnography is useful for monitoring respiratory rate and pattern, but may present difficulties in interpretation of actual PaCO2. Indirect blood pressure monitoring is not accurate by use of current methods in ferrets.
评估麻醉状态下家养雪貂间接生理监测技术的仪器放置及准确性。
10只健康成年雌性雪貂（欧洲雪貂）。
对雪貂进行直接动脉血压测量及动脉血样本采集。将脉搏血氧饱和度仪探头夹在前足或后足；将用于二氧化碳描记术的气道适配器连接至气管插管；将血压计袖带和多普勒血流探头置于尾部。分别改变异氟烷和氧化亚氮浓度以诱导低血压或低氧血症发作。将上述非侵入性技术与动脉血气分析、血液氧含量测定及动脉血压测量的直接方法进行比较。对同时获得的直接和间接测量结果的差异均值、标准差及标准误进行统计学评估，并主观评估其易用性及与临床情况的相关性。
脉搏血氧饱和度测定获得的值与通过血气分析测得的氧饱和度（O2sat）密切相关。所有结果的平均（±标准差）差异为-0.49（±-4.09）%。当O2sat在90%至100%之间时，获得的测量结果最精确。二氧化碳描记术测量结果在不同范围内变化。当动脉血二氧化碳分压（PaCO2）<25 mmHg时，获得的测量结果最准确，此时平均差异为1.6（±-3.01）mmHg。间接血压测量始终低估直接血压值。
脉搏血氧饱和度测定是监测家养雪貂氧饱和度的便捷且准确的方法。二氧化碳描记术有助于监测呼吸频率和模式，但在实际PaCO2的解读方面可能存在困难。采用当前方法在家养雪貂中进行间接血压监测并不准确。
