Valdés-Dapena M A, Nissim J E, Arey J B, Godleski J, Schaaf H D, Haust M D
J Pediatr. 1976 Jul;89(1):128-32. doi: 10.1016/s0022-3476(76)80947-x.
Yellow pulmonary hyaline membranes were observed at autopsy in 16 newborn infants between 1972 and 1974 in four hospitals of Philadelphia, Pa., and Newark, N.J. Other pediatric pathologists in this country and in Spain have seen the same lesion within the last decade. Chemical analysis of affected lung tissue, histochemistry, and electron microscopy show the yellow color to be due to the presence of bilirubin. No substantial clues concerning the basic etiology or mechanism for the formation of these unique membranes emerge from a detailed review of clinical and postmortem data nor from comparison of these data with those for 68 control infants with the usual acidophilic pulmonary hyaline membranes. We are left, however, with the impression that prolongation of life, relatively elevated levels of serum bilirubin, and protracted assisted ventilation (with either CPAP or PEEP) are intimately related to their formation.
1972年至1974年间，在宾夕法尼亚州费城和新泽西州纽瓦克的四家医院对16名新生儿进行尸检时观察到黄色肺透明膜。在过去十年中，该国和西班牙的其他儿科病理学家也见过同样的病变。对受影响的肺组织进行化学分析、组织化学和电子显微镜检查表明，黄色是由于胆红素的存在。对临床和尸检数据进行详细回顾，以及将这些数据与68例患有常见嗜酸性肺透明膜的对照婴儿的数据进行比较，均未发现有关这些独特膜形成的基本病因或机制的实质性线索。然而，我们的印象是，延长生命、血清胆红素水平相对升高以及长时间辅助通气（使用持续气道正压通气或呼气末正压通气）与它们的形成密切相关。
